So far this year, B-MRS member Navadeep Shrivastava has won four awards for his work on materials with magnetic and luminescent properties developed in the context of his doctoral research being conducted at the Federal University of Maranhão (UFMA) under the guidance of Professor Surender Kumar Sharma.
In February, Shrivastava was selected to receive a registration exemption at the E-MRS 2017 Spring Meeting, within an existing agreement between B-MRS and the European Materials Research Society (E-MRS). The award allowed the participation of the doctoratal student in the event, which was held in Strasbourg (France) from 22 to 26 May 2017.
At the E-MRS event, Shrivastava won an award for the poster he presented at the symposium entitled “Luminescence and Magnetic Behavior of Color Tuned LaF3:RE3+ (RE= Ce, Gd, Eu) Nanoparticles”. In addition, he presented another contribution at symposium V (“Green emitting magneto-luminescent iron-oxide/ZnS coated by codoped lanthanum fluoride nanomaterials”), which drew the attention of the audience, initiated a collaborative relationship with a group from the Université de Strasbourg (France) and expanded his network of professional contacts. “I want to express my gratitude for the opportunity to participate in the E-MRS 2017 Spring Meeting,” says Shrivastava.
In third place, the doctoral student was one of the winners of the 2017 Bernhard Gross Award, awarded by SBPMat to the best works presented by students at the annual events of the society. Shrivastava was awarded for the work “Facile synthesis and magneto-luminescence study of aliance of iron oxide and NaGdF4:RE3+ into nanoentity”, presented in an oral session at symposium B. The award was delivered on September 14 this year in the city of Gramado, during the closing ceremony of the XVI B-MRS Meeting.
Finally, the UFMA PhD student has just been selected to receive a travel assistance from the IEEE Magnetics Society to present two papers at the 62nd edition of the International Conference on Magnetism and Magnetic Materials, called MMM 2017, to be held in Pittsburgh in November of this year.
“Luminescence applied to nanomedicine” is the subject of one of the plenary lectures that the Materials research community is going to enjoy in our XIII SBPMat Meeting (João Pessoa, Brazil, September 28th to October the 2nd). The speaker will be the Portuguese physicist Luís António Ferreira Martins Dias Carlos, full professor at the University of Aveiro (Portugal), who got his Ph.D. in physics from the University of Évora (Portugal) in 1995 working on photoluminescence of polymer electrolytes incorporating lanthanide salts.
At the University of Aveiro, Luís Carlos created in 2000 a research group in functional organic-inorganic hybrids. The group has established an international network devoted to these luminescent hybrid materials with more than 30 research groups in Europe, China, Japan, Singapore, Brazil and Australia. Also at Aveiro, Luís Carlos has been, since 2009, the vice-director of the Centre for Research in Ceramics and Composite Materials (CICECO), one of the largest European institutes in the Materials and Nano fields.
He is member of the Lisbon Academy of Sciences (Physics section) since 2011. He was visiting professor of São Paulo State University (UNESP), Brazil, in 1999, 2012 and 2013, and of University of Montpellier 2, France, in 2008. He awarded a ‘Pesquisador Visitante Especial’ grant by the CNPq, Science Without Borders Program, Brazil in 2013.
He has co-authored more than 345 papers in international journals, 8 invited reviews, 5 book chapters, and 2 international patents. He has more than 8.050 citations, having h-index of 47. He has given 40 plenary and invited lectures at conferences. He is associate editor of the Journal of Luminescence.
Read our interview with the plenary speaker.
SBPMat newsletter: – Are there nanomedical applications to luminescent materials already on the market/spread in society? Please, give some high-impact examples.
Luís Carlos: – Undoubtedly yes, there are luminescent materials with important applications in nanomedicine already on the market. I can highlight two examples:
1. Organic complexes based on lanthanide ions (as, for example, cryptates and β-diketonates) are sold as contrast agents for magnetic resonance imaging (essentially using Gd³+) and luminescent markers (using Eu3+, Sm3+ and Tb3+) for fluoroimmunoassays. The fluoroimmunoassay is an immunological method for clinical diagnosis that is particularly relevant in prenatal and neonatal screening tests, as well as to detect proteins, viruses, antibodies, tumor biomarkers and medicine residues. In this respect, it is worth mentioning the work conducted by several researchers from the INCT INAMI (Brazilian National Institute of Science and Technology on Nanotechnology for Integrated Markers), implementing a prototype in the hospital environment in order to develop methods to diagnose the American cutaneous leishmaniasis, prostate cancer (PSA) and low density lipoprotein (LDL) by fluoroimmunoassay, using recombinant antigens marked with lanthanide ions complexes (for example, Eu3+, Tb3+ and Nd3+). The international market for contrast agents and luminescent markers based on lanthanide ions is valued in many hundreds of millions of US dollars.
2. Luminescent nanoparticles (“quantum dots”, QDs, and nanocrystals incorporating lanthanide ions) have played a major role in the last years thanks to very important applications for diagnosis by optical imaging and therapy techniques. Recent estimates value the international market for luminescent nanoparticles in the medical field in over 20 million US dollars. A notable example in the treatment of tumors is the local hyperthermia. Local hyperthermia, also referred as local thermotherapy, is a type of treatment in which biological tissues (typically cancer cells) are exposed to temperatures above 45° C, irreversibly damaging them and causing their death (the collateral damage to the healthy tissues surrounding the tumor is usually minimal). Numerous clinical trials with hyperthermia are being currently performed around the world so we can better comprehend and improve the technique. For example, the use of luminescent or magneto-luminescent particles (with magnetic ions such as Iron or Cobalt), vectored to bind to specific points in the cancer cells, enabling the local heating by the absorption of electromagnetic radiation and magnetic induction, respectively, is a new type of local hyperthermia. Precise temperature control in the irradiated area, limiting the effects of high temperature on the rest of the body, still is one of the key challenges for the popularization of the technique.
SBPMat newsletter: – Could you briefly describe the main challenges in the field of luminescence applied to nanomedicine?
Luís Carlos: – I can point out two examples: improving the imaging techniques for diagnosis and developing luminescent micro/nanothermometers which allow mapping the intracellular temperatures with a resolution of the order of tenths of a degree.
In regard to imaging applications in nanomedicine, emitting centers in the near-infrared region (for example, lanthanide ions such as Nd3+ and Yb3+, QDs and organic dyes) have great advantages over those in the visible region. For instance, biological tissues present less autofluorescence in the near-infrared window, which enables a better signal-to-noise discrimination and improves the sensibility to detection. Also, in comparison to the ones in the visible region, near-infrared photons interact less with biological tissues, which reduces the risk of disturbance or damage in the observed biological system. Thus, there is no doubt that the synthesis of new luminescent nanoparticles, emitting efficiently in near-infrared (in some cases producing persistent luminescence, i.e., light emissions that last for minutes, hours or even days, after the excitation is over), will lead us to a revolution in fluorescence microscopy, with the development of in vitro and in vivo imaging techniques in near-infrared (whose radiation penetrates deeper into the biological tissue, when compared to visible light).
The development of luminescent micro/nanothermometers to map the intracellular temperature, particularly in cancer cells, will surely improve our current perception on their pathology and physiology, optimizing early diagnosis and therapeutic processes (as seen above in the case of local hyperthermia). These non-invasive thermometers are a critical tool for better understanding a set of cellular processes followed by alterations in temperature, such as cell division, gene expression, or changes in the metabolic activity. Finally, the development of luminescent nanothermometers in the near-infrared region, which are capable of sensing heat and penetrate deeper into the biological tissue, will pave the way for in vivo thermal sensing and imaging (in small animals, in a first stage).
SBPMat newsletter: – Under your viewpoint, which are the main contributions you made to the field of Materials Science and Engineering during your scientific career? Could you please include a selection of 3 or 4 of the most important publications among your work in your answer?
Luís Carlos: – Normally, our latest works tend to seem to be the most important… Regardless, I understand that my main contributions to Materials Science and Engineering are related to the development of i) luminescent organic-inorganic hybrid materials, ii) ratiometric nanothermometers based on the characteristic emission of lanthanide ion pairs (Eu3+/Tb3+ and Er3+/Yb3+) and iii) nanoplatforms combining nanoheaters (metal particles of Gold or Silver) and nanothermometers which allow to increase the local temperature by laser irradiation while simultaneously mapping such temperature increase with precision. The following four papers illustrate these contributions:
Full Colour Phosphors From Eu(III)-Based Organosilicates. L. D. Carlos, Y. Messaddeq, H. F. Brito, R. A. Sá Ferreira, V. de Zea Bermudez, S. J. L. Ribeiro, Adv. Mater. 12, 594–598 (2000)
Nanoscopic Photoluminescence Memory as a Fingerprint of Complexity in Self-Assembled Alkylene/Siloxane Hybrids. L. D. Carlos, V. de Zea Bermudez, V. S. Amaral, S. C. Nunes, N. J. O. Silva, R. A. Sá Ferreira, J. Rocha, C. V. Santilli, D. Ostrovskii, Adv. Mater. 19 341–348 (2007)
A Luminescent Molecular Thermometer for Long-Term Absolute Temperature Measurements at the Nanoscale. C. D. S. Brites, P. P. Lima, N. J. O. Silva, A. Millán, V. S. Amaral, F. Palacio, L. D. Carlos, Adv. Mater. 22, 4499–4504 (2010)
All-In-One Optical Heater-Thermometer Nanoplatform Operative From 300 to 2000 K Based on Er3+ Emission and Blackbody Radiation. M. L. Debasu, D. Ananias, I. Pastoriza-Santos, L. M. Liz-Marzan, J. Rocha, L. D. Carlos, Adv. Mater. 25, 4868–4874 (2013)