Nanotechnology is a strategic industrial and economic sector showing enormous potential benefits for many society and environmental domains. The lack of scientific knowledge and the absence of evidence demonstrating the safety of some nanomaterials make regulation a challenge. Various agencies around the world are providing specific regulatory guidelines for such materials before their commercialization. In this context, toxicology studies are providing information to guide regulatory decisions toward developing a safety regulatory network to enable the marketing of products. In this context, we would like to propose the symposium "Nanotoxicology and Nanoregulation - the safe use of manufactured nanomaterials". This symposium will be the second nanotoxicology meeting in SBPMat-Brazil that will discuss the toxicology aspects of nanomaterials, which is increasing over the world by international conferences that has included Nanosafe and Nanotoxicology. Moreover, it will be the opportunity to the NanoReg Brazil meeting. The symposium welcomes all researchers in the field of Nanoscience and Nanotechnology that is interesting in the toxicology field. Brazilian and Europeans researchers, in particular, are invited to participate in the symposium as a way of identifying partners and potential collaborative projects between Brazil and EU, following the collaborative research program launched in 2014 by Ministry of Science, Technology and Innovation of Brazil (MCTI) and Inmetro. The symposium will create opportunities for participants to present and share experiences, explore new directions and debate topics with experts from across the globe in the field of nanotoxicology.